Interaction of central nervous system drugs with synaptosomal transport processes

Interaction of central nervous system drugs with synaptosomal transport processes.

Interaction of a wide range of central nervous system (CNS) drugs with the transport of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) into synaptosomes from cerebral cortex was investigated. By determining the effect on Na,K-ATPase, the interaction of these drugs with the synaptic transport of Naf and K + was also assessed. Although of different numerical value, the order of potency of the...

Drugs in Central Nervous System Disorders

This book is the second in a series entitled "Clinical Pharmacology," edited by Murray Weiner. The volume contains six chapters, of varying quality, by authors who have been researchers in the area of neuropharmacology. The first chapter, "Centrally Acting Analgesics," is a well-documented (517 references), timely, and complete review of the newest research in the pharmacology and physiology of...

Drugs Affecting the Central Nervous System

24. Introduction to Central Nervous System Pharmacology 281 Charles R. Craig 25.General Anesthesia: Intravenous and Inhalational Agents 291 David J. Smith and Michael B. Howie 26.Opioid and Nonopioid Analgesics 310 Sandra P. Welch and Billy R. Martin 27.Local Anesthetics 330 J. David Haddox 28.Agents Affecting Neuromuscular Transmission 338 Michael D. Miyamoto 29.Central Nervous System Stimulan...

[Drugs acting on the central nervous system].

ADENOSINE IN THE CENTRAL NERVOUS SYSTEM

Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...